Search results for "TTV DNAemia"

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Dynamics of Torque Teno virus plasma DNAemia in allogeneic stem cell transplant recipients

2017

Abstract Background Torque Teno virus (TTV) plasma DNA load directly correlate with the level of immunosuppresion in different clinical settings. It is uncertain whether this may be the case in allogeneic hematopoietic stem cell transplant recipients (allo-HSCT). Objectives We characterized the dynamics of TTV DNAemia in patients undergoing T-cell replete allo-SCT. Study design Retrospective single-center observational study including 72 allo-HSCT patients. Plasma TTV DNA loads were quantified before initiating the conditioning regimen and at different time-points after transplant by real-time PCR. White blood cells (WBC) and absolute lymphocyte counts (ALC) were measured by flow cytometry.…

0301 basic medicineAdultMaleHomologousTorque teno virusAdolescentLymphocyteAllogeneic hematopoietic stem cell transplantation (Allo-HSCT); Immune reconstitution; Torque Teno virus (TTV); TTV DNAemia; Adolescent; Adult; Aged; DNA Virus Infections; DNA Viral; Female; Humans; Immunocompromised Host; Leukocyte Count; Male; Middle Aged; Retrospective Studies; Torque teno virus; Transplantation Homologous; Viral Load; Viremia; Young Adult; Hematopoietic Stem Cell Transplantation; Virology; Infectious Diseases030106 microbiologyTTV DNAemiaFlow cytometry03 medical and health sciencesImmunocompromised HostLeukocyte CountYoung AdultVirologyMedicineTransplantation HomologousHumansIn patientViralViremiaProspective cohort studyAgedRetrospective StudiesTorque teno virusTransplantationmedicine.diagnostic_testbusiness.industryHematopoietic Stem Cell TransplantationDNAImmune reconstitutionMiddle AgedViral LoadDNA Virus Infectionssurgical procedures operative030104 developmental biologymedicine.anatomical_structureInfectious DiseasesAllogeneic hematopoietic stem cell transplantation (Allo-HSCT); Immune reconstitution; Torque Teno virus (TTV); TTV DNAemia; Adolescent; Adult; Aged; DNA Virus Infections; DNA; Viral; Female; Humans; Immunocompromised Host; Leukocyte Count; Male; Middle Aged; Retrospective Studies; Torque teno virus; Transplantation; Homologous; Viral Load; Viremia; Young Adult; Hematopoietic Stem Cell Transplantation; Virology; Infectious DiseasesImmunologyDNA ViralAllogeneic hematopoietic stem cell transplantation (Allo-HSCT)FemaleAllogeneic hematopoietic stem cell transplantStem cellImmunocompetencebusinessTorque Teno virus (TTV)
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Kinetics of torque teno virus DNA load in saliva and plasma following allogeneic hematopoietic stem cell transplantation

2018

Plasma torque teno virus (TTV) DNA load directly correlates with the degree of T-cell immune reconstitution early after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, the kinetics of oral TTV DNA shedding was examined to assess whether quantitation of TTV DNA load in saliva may either replace or complement that in plasma for predicting lymphocyte (ALC) reconstitution after engraftment. This prospective observational study enrolled 38 nonconsecutive allo-HSCT recipients. Saliva and plasma specimens were collected at baseline (pretransplant) and at around days +30, +50, and +90 after allo-HSCT. TTV DNA was quantitated in both specimen types by real-time PCR. ALCs were m…

AdultMale0301 basic medicineTorque teno virusSalivaOral TTV DNA sheddingLymphocytemedicine.medical_treatmentTTV DNAemiaAllogeneic hematopoietic stem cell transplantation (allo-HSCT)Hematopoietic stem cell transplantationReal-Time Polymerase Chain ReactionTorque teno virus (TTV)Plasma03 medical and health sciences0302 clinical medicineImmune systemVirologymedicineHumansTransplantation HomologousProspective StudiesAllogeneic hematopoietic stem cell transplantation (allo-HSCT); Immune reconstitution; Oral TTV DNA shedding; Saliva; Torque teno virus (TTV); TTV DNAemia; Virology; Infectious DiseasesSalivaAgedTorque teno virusbusiness.industryHematopoietic Stem Cell TransplantationMiddle AgedImmune reconstitutionVirologyDNA Virus InfectionsTransplantation030104 developmental biologyInfectious Diseasesmedicine.anatomical_structureReal-time polymerase chain reactionDNA ViralFemalebusinessCytometry030215 immunologyJournal of Medical Virology
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